On May 29, 2025, Perpetual Life hosted a groundbreaking hybrid service streamed live, featuring three world-renowned experts sharing the latest research in cardiac arrest prevention, longevity nutrition, and age reversal technologies. This service brought together Dr. Mitch Ghen, Bill Faloon, and Jeff Palmer — each addressing crucial aspects of extending the human healthspan and lifespan.
Their insights represent the convergence of advanced biochemical testing, emerging gene therapies, and new nutritional frontiers. Below, we provide a comprehensive review of their talks, packed with actionable takeaways, up-to-date scientific references, and deep-diving analysis.
Overview of the May 29 Longevity Service
This diagram summarizes the main themes from the May 29 Church of Perpetual Life service
Full Service Replay: May Service: Cardiac Arrest Prevention, Longevity Nutrition & Age Reversal
*Recorded live on May 29, 2025 at the Church of Perpetual Life featuring Bill Faloon, Geoff Palmer, and Dr. Mitch Ghen.
The Biochemical Root of Longevity: Dr. Mitch Ghen’s Integrative Medicine Approach
Dr. Mitch Ghen, with over 38 years of experience in anti-aging and integrative medicine, delivered a highly technical presentation on how personalized biochemistry is the critical foundation for true health optimization and life extension.
Testing 155 Biochemical Markers: The “Human Diagnostic Dashboard”
One of Dr. Ghen’s most vital points was the sheer complexity of the human body: each of us undergoes over 680 trillion biochemical reactions every second. While most conventional physicians run a handful of blood tests, Dr. Ghen emphasized the need for comprehensive biochemical panels of 155+ markers per patient.
Key tests include:
- Inflammatory markers (CRP, homocysteine, cytokine panels)
- Full thyroid panel (TSH, Free T3, Free T4, reverse T3, antibodies)
- Complete hormone profile (testosterone, estrogen, DHEA, pregnenolone, IGF-1)
- Intracellular minerals (magnesium, zinc)
- Nutritional deficiencies (vitamin D, B12, methylation panels)
- Oxidative stress markers (oxidized LDL, lipid peroxides)
- Advanced cardiovascular panels (Lp(a), APOE, HDL subfractions)
- Autonomic nervous system testing
“Testing only a few markers is like flying an airplane without full instrumentation,” Dr. Ghen remarked.
Biochemistry + Physiology = Personalized Medicine
Dr. Ghen explained that optimizing longevity involves not only biochemical data but also physiological assessmentssuch as autonomic nervous system testing — which can detect early dysfunctions that often precede chronic diseases by decades.
Many disorders, including arrhythmias, hypertension, metabolic syndrome, and neurodegeneration, originate from autonomic dysregulation.
Nutrient Dosing Must Be Personalized
Dr. Ghen cautioned against following generic online supplement protocols. For example, excessive doses of certain vitamins may actually create additional deficiencies via competition for receptor sites. Instead, he advocates intravenous nutrient delivery — offering 100% bioavailability — customized to each patient’s exact biochemical fingerprint.
This high-precision approach, he argued, offers the best chance to reverse aging processes at the cellular level.
FAQ: Cardiac Arrest Prevention, Longevity Nutrition & Age Reversal (2025 Insights)
What makes cardiac arrest different from a heart attack?
While a heart attack typically involves blocked arteries reducing blood flow to the heart muscle, cardiac arrest prevention focuses on the sudden electrical malfunction of the heart. In cardiac arrest, the heart’s rhythm becomes erratic or stops entirely, halting blood circulation instantly. Many patients who suffer cardiac arrest have no significant arterial blockages, making prevention strategies such as physical fitness, social engagement, and glucosamine supplementation even more crucial.
Why is glucosamine effective for cardiac arrest prevention?
Surprisingly, glucosamine supplementation was shown in the UK Biobank study to lower cardiac arrest risk by approximately 20%. Though originally used for joint health, glucosamine’s anti-inflammatory properties likely contribute to vascular and metabolic stability, indirectly benefiting cardiac rhythm regulation. Its exact protective mechanisms are still being researched.
How do Yamanaka factors reverse aging at the cellular level?
Yamanaka factors (OSK gene therapy)—Oct4, Sox2, and Klf4—reprogram cellular DNA to reverse methylation damage, effectively returning old cells to a youthful state. This process restores cell function, improves tissue regeneration, and may dramatically slow or even reverse biological aging, as seen in promising animal studies.
Is OSK gene therapy available for humans right now?
Not yet. As of 2025, OSK gene therapy is still in the experimental phase. Bill Faloon’s team is targeting 2026 clinical trials on humans after safety and efficacy tests in non-human primates. If successful, OSK gene therapy could become a landmark breakthrough in age reversal gene therapy.
What makes mycelium a superior protein and nutrient source?
Mycelium offers complete protein, rich fiber (chitin), beta-glucans for immune support, and exceptionally high mycelium spermidine benefits—with concentrations far exceeding traditional plant or animal foods. It’s also sustainable, requiring fewer resources to grow compared to livestock or crops.
How does spermidine stimulate autophagy?
Spermidine activates autophagy—the process by which cells clear out damaged proteins and organelles. This cellular “housecleaning” maintains optimal cell function, reduces inflammation, and extends longevity. Spermidine achieves autophagy benefits without requiring fasting or calorie restriction, making it especially attractive for aging populations.
Are synthetic spermidine supplements as effective as food-based ones?
No. Research suggests that synthetic or isolated spermidine may have poor bioavailability because it’s not recognized as food by the digestive system. Whole-food sources, such as fermented mycelium products, offer far superior absorption and safety profiles, ensuring the nutrient reaches cells where it’s needed.
Why does social isolation increase cardiac arrest risk?
Lack of social interaction contributes to chronic stress, depression, poor lifestyle choices, and even physiological changes that destabilize heart rhythm. The UK Biobank study identified social isolation and unemployment as leading modifiable risk factors for sudden cardiac arrest.
What role does precision medicine play in longevity?
Precision medicine uses extensive biochemical analysis—like the 155+ markers suggested by Dr. Ghen—to create highly individualized treatment protocols. By understanding each person’s hormonal, nutritional, inflammatory, and genetic status, doctors can design more effective longevity and disease prevention plans.
What simple steps can I take right now to improve longevity?
You can begin immediately by:
- Increasing vigorous physical activity
- Reducing or quitting smoking
- Enhancing social engagement
- Considering safe spermidine supplementation
- Seeking comprehensive biochemical testing
Consulting with specialists in advanced nutrition science and gene therapy developments
Preventing Sudden Cardiac Arrest: Bill Faloon’s Evidence-Based Strategies
Bill Faloon, co-founder of Life Extension Foundation and a leading advocate for evidence-based life extension, focused his presentation on one of the most urgent threats to middle-aged and older adults: sudden cardiac arrest.
While many people think of blocked arteries as the primary threat, Faloon explained that ventricular fibrillation without arterial blockage (electrical dysfunction) accounts for a large share of sudden cardiac deaths.
2025 UK Biobank Study: 500,000+ Subjects Over 13 Years
Drawing on newly published data from the UK Biobank study (2025), Faloon outlined a detailed list of modifiable factors that significantly alter cardiac arrest risk.
Top Protective Factors (risk reduction of 40-63%):
- Vigorous physical activity
- Moderate physical activity
- Walking regularly
- Glucosamine supplementation
- Healthy social relationships
- Ongoing employment or intellectual engagement
- Maintaining normal weight (BMI)
- Adequate sleep quality
- Nut consumption
- Higher educational attainment
- Low depression and anxiety levels
Top Risk Factors (increased cardiac arrest risk):
- Smoking (active and former smokers)
- Excessive egg intake (>1 egg/day)
- Obesity
- Poor sleep quality
- Chronic unemployment
- Social isolation
- Clinical depression
- Alcohol excess
- Low educational status
“Not being employed was the #1 independent risk factor for sudden cardiac death in this cohort,” Faloon emphasized.
Cardiac Arrest vs. Heart Attack: Key Distinction
Faloon distinguished between myocardial infarction (heart attack) due to arterial blockage and sudden cardiac arrest due to electrical conduction failure, which may occur even in people with clean arteries.
This distinction explains why some seemingly healthy, athletic individuals (including young athletes) suddenly collapse and die — unless quickly resuscitated via defibrillation.
The Broader Implications for Longevity Medicine
Faloon argued that many of these same modifiable risk factors also intersect with general aging pathways, supporting the importance of lifestyle interventions to prevent:
- Hypertension
- Metabolic syndrome
- Neurodegeneration
- Sarcopenia (muscle loss)
He cited Framingham Heart Study data, as well as newer findings on epigenetic aging markers, to support these conclusions.
Yamanaka Factors: 2026 Human Clinical Trial Goal
Perhaps the most ambitious part of Faloon’s talk was his update on gene therapy research.
Faloon is personally funding development of OSK Yamanaka factor gene therapies, which have already reversed aging markers in mouse studies. The delivery method uses lipid nanoparticles and polymer-based delivery systemsto insert rejuvenation signals into aging DNA.
The team has already begun mouse and primate trials in 2025. If primate results succeed, Faloon’s stated goal is to initiate human clinical trials in 2026, potentially marking a historic leap toward biological age reversal.
“If we can rejuvenate aging monkeys with OSK, we could finally see a pathway to widespread clinical reversal of human aging.”
The Mycelium Frontier: Jeff Palmer’s Breakthrough on Spermidine
Jeff Palmer, founder of Clean Machine, focused his presentation on emerging research involving spermidine, a polyamine compound strongly correlated with increased healthspan and lifespan across multiple species.
Mycelium vs. Conventional Food Sources
While most dietary spermidine discussions center on wheat germ, natto, and mushrooms, Palmer presented new data on mycelium-grown protein substrates (specifically Rhizopus oryzae strains), which may allow for higher yields of naturally occurring spermidine through controlled fermentation.
Palmer described how industrial mycelium growth offers sustainable, ecologically responsible protein production with unique additional bioactives — including beta-glucans, chitin fibers, and potential polyamine enrichment.
However, as current data suggests, the absolute spermidine content per gram of mycelium remains modest relative to wheat germ (~1.2 mg/g for wheat germ vs. typically much lower for most mycelium strains under normal conditions). Palmer’s laboratory claims higher concentrations via strain selection and bioreactor optimization, but this will require peer-reviewed confirmation.
Spermidine’s Mechanism: Activating Autophagy
Spermidine is emerging as one of the few natural compounds shown to activate autophagy, the cellular self-cleaning process critical for:
- Removing dysfunctional mitochondria
- Clearing senescent (zombie) cells
- Maintaining metabolic health
- Preventing neurodegeneration
Palmer cited research demonstrating that spermidine:
- Prolongs lifespan in animal models
- Reduces cardiovascular disease risk
- Improves hair, skin, and cognitive function
- Lowers incidence of allergies (especially in infancy via maternal transfer)
“Spermidine works upstream of both fasting and rapamycin — both require spermidine for full effect,” ~ Palmer emphasized.
Safety Profile and Supplementation Considerations
Palmer also discussed why synthetic spermidine supplements may be poorly absorbed compared to food-based spermidine. Current human trials typically use doses of 1–10 mg/day derived from natural food sources.
His company is developing a mycelium-based food product with high spermidine content scheduled for release later in 2025.
The Convergence: Personalized, Preventive, and Regenerative Medicine
Together, the three presentations demonstrate how the future of longevity nutrition, cardiac arrest prevention, and age reversal research is converging into a more sophisticated, multi-layered science.
- Dr. Ghen: Personalized biochemical optimization is foundational.
- Bill Faloon: Lifestyle and gene therapy can prevent catastrophic decline.
- Jeff Palmer: Nutritional bioactives like spermidine support cellular housekeeping.
All three speakers emphasized that early action is essential. Waiting until serious disease develops leaves little room for full recovery.
RAADfest & the Longevity Community
The service echoed the energy of RAADfest (Revolution Against Aging and Death Festival) — a global gathering where visionaries, scientists, and activists unite under the shared goal of extending human life. Speakers at the Church of Perpetual Life emphasized that real breakthroughs happen not only in labs, but through communal education, shared resources, and spiritually aligned science. The blending of secular research with a purpose-driven faith cultureallows for a deeply human approach to radical life extension. With regular attendees coming from all over the world, this longevity-focused community fosters cross-pollination of ideas between supplement innovators, biohackers, cryonics supporters, and spiritual optimists.
Conclusion: Act Now, Prepare for the Future
As Bill Faloon wisely stated:
“The most important decision you can make is whether to proactively intervene — or passively wait for decline.”
Whether your interest lies in optimizing your biochemistry, upgrading your nutrition, or exploring gene therapy, the science is advancing at historic speed. What was once speculative fiction is rapidly becoming applied clinical reality.
Call to Action
If you’re serious about improving your healthspan, don’t wait for perfect solutions. Start optimizing your biochemistry today, investigate emerging nutritional therapies like spermidine, and follow cutting-edge gene therapy developments closely.
To stay informed on future services like this one, sign up for our newsletter or join the expanding international community of researchers and participants reshaping the future of longevity science.
Further Reading and References
- UK Biobank Sudden Cardiac Arrest Study 2025
- Spermidine is essential for fasting-mediated autophagy and longevity
- Framingham Heart Study Official Data
Disclaimer
Perpetual Life emphasized that the service was intended to provide non-commercial, educational information about novel ways of extending healthy human lifespans. The insights, strategies, and scientific discussions presented were for informational purposes only and not meant to serve as medical advice or endorsements of specific treatments. Attendees were encouraged to consult with qualified healthcare professionals before making any health-related decisions.
Collaboration Notice
This long form blog post summary was created in collaboration with a research AI assistant to enhance accuracy, formatting, and synthesis of complex longevity science. The service highlighted the collaborative efforts between the Church of Perpetual Life and leading experts in the fields of longevity and age reversal. Notably, the service featured presentations by:
- Dr. Mitch Ghen on root cause medicine and optimal health strategies.
- Geoff Palmer on breakthroughs in longevity nutrition, particularly the benefits of spermidine-rich mycelium.
- Bill Faloon, co-founder of the Age Reversal Network, discussing modifiable risk factors for sudden cardiac arrest and integrating age reversal research.
These collaborations aimed to provide attendees with a comprehensive understanding of current advancements in longevity science.
